ON-LINE SOLID PHASE EXTRACTION COUPLED WITH LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY FOR THE DETERMINATION OF CODEINE IN HUMAN PLASMA

ON-LINE SOLID PHASE EXTRACTION COUPLED WITH LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY FOR THE DETERMINATION OF CODEINE IN HUMAN PLASMA

A specific LC-MS/MS method was developed and validated for automated determination of codeine in human plasma, using on-line solid phase extraction (SPE) system coupled with positive ion electrospray ionization tandem mass spectrometry. The method allowed plasma direct injection onto cartridge witho...

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Bibliographic Details
Main Authors: Alessandro de C. Cruz, Eunice M. Suenaga, Eduardo Abib, José Pedrazzoli
Format: Article
Language:English
Published: Sociedade Brasileira de Química
Series:Química Nova
Subjects:
on-line SPE
LC-MS/MS
high-throughput
monolithic column
codeine
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422017000100025&lng=en&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422017000100025&lng=en&tlng=en

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