MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4γ-dependent transcription of CES enzymes

MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4γ-dependent transcription of CES enzymes

Summary: Enterocytes modulate the extent of postprandial lipemia by storing dietary fats in cytoplasmic lipid droplets (cLDs). We have previously shown that the integrin ligand MFGE8 links absorption of dietary fats with activation of triglyceride (TG) hydrolases that catabolize cLDs for chylomicron...

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Bibliographic Details
Main Authors: Ritwik Datta, Mohammad A. Gholampour, Christopher D. Yang, Regan Volk, Sinan Lin, Michael J. Podolsky, Thomas Arnold, Florian Rieder, Balyn W. Zaro, Michael Verzi, Richard Lehner, Nada Abumrad, Carlos O. Lizama, Kamran Atabai
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Cell Reports
Subjects:
CP: Metabolism
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723002607

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http://www.sciencedirect.com/science/article/pii/S2211124723002607

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