<i>KRAS</i> p.G12C Mutation in Metastatic Colorectal Cancer: Prognostic Implications and Advancements in Targeted Therapies

<i>KRAS</i> p.G12C Mutation in Metastatic Colorectal Cancer: Prognostic Implications and Advancements in Targeted Therapies

<i>KRAS</i> is frequently mutated in tumors. It is mutated in approximately 30% of all cancer cases and in nearly 50% of cases of metastatic colorectal cancer (CRC), which is the third leading cause of cancer-related deaths worldwide. Recent advancements in understanding CRC biology and...

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Bibliographic Details
Main Authors: Alessandro Ottaiano, Francesco Sabbatino, Francesco Perri, Marco Cascella, Roberto Sirica, Renato Patrone, Maurizio Capuozzo, Giovanni Savarese, Monica Ianniello, Nadia Petrillo, Luisa Circelli, Vincenza Granata, Massimiliano Berretta, Mariachiara Santorsola, Guglielmo Nasti
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cancers
Subjects:
KRAS
genetics
prognosis
p.G12C mutation
metastatic colorectal cancer
Online Access:https://www.mdpi.com/2072-6694/15/14/3579

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https://www.mdpi.com/2072-6694/15/14/3579

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