Neutralizing antibodies elicited in macaques recognize V3 residues on altered conformations of HIV-1 Env trimer

Neutralizing antibodies elicited in macaques recognize V3 residues on altered conformations of HIV-1 Env trimer

Abstract Eliciting broadly neutralizing antibodies that protect against diverse HIV-1 strains is a primary goal of AIDS vaccine research. We characterized Ab1456 and Ab1271, two heterologously-neutralizing antibodies elicited in non-human primates by priming with an engineered V3-targeting SOSIP Env...

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Bibliographic Details
Main Authors: Andrew T. DeLaitsch, Jennifer R. Keeffe, Harry B. Gristick, Juliet A. Lee, Wenge Ding, Weimin Liu, Ashwin N. Skelly, George M. Shaw, Beatrice H. Hahn, Pamela J. Björkman
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-024-01038-0

Internet

https://doi.org/10.1038/s41541-024-01038-0

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