Tuning Scorpion Toxin Selectivity: Switching From KV1.1 to KV1.3

Tuning Scorpion Toxin Selectivity: Switching From KV1.1 to KV1.3

Voltage-gated potassium channels (KVs) perform vital physiological functions and are targets in different disorders ranging from ataxia and arrhythmia to autoimmune diseases. An important issue is the search for and production of selective ligands of these channels. Peptide toxins found in scorpion...

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Bibliographic Details
Main Authors: Andrei M. Gigolaev, Alexey I. Kuzmenkov, Steve Peigneur, Valentin M. Tabakmakher, Ernesto L. Pinheiro-Junior, Anton O. Chugunov, Roman G. Efremov, Jan Tytgat, Alexander A. Vassilevski
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Pharmacology
Subjects:
scorpion venom
neurotoxin
voltage-gated potassium channel
potassium channel blocker
molecular modeling
molecular dynamics
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01010/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.01010/full

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