African Swine Fever Virus MGF360-14L Negatively Regulates Type I Interferon Signaling by Targeting IRF3

African Swine Fever Virus MGF360-14L Negatively Regulates Type I Interferon Signaling by Targeting IRF3

African swine fever (ASF) is a devastating infectious disease caused by African swine fever virus (ASFV). The ASFV genome encodes multiple structural and non-structural proteins that contribute to evasion of host immunity. In this study, we determined that the viral non-structural protein MGF360-14L...

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Bibliographic Details
Main Authors: Yang Wang, Shuai Cui, Ting Xin, Xixi Wang, Hainan Yu, Shiyu Chen, Yajun Jiang, Xintao Gao, Yitong Jiang, Xiaoyu Guo, Hong Jia, Hongfei Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
African swine fever virus
interferon
IRF3
ubiquitination
immune evasion
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.818969/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2021.818969/full

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