Design, synthesis, and pharmacological evaluation of 2-amino-5-nitrothiazole derived semicarbazones as dual inhibitors of monoamine oxidase and cholinesterase: effect of the size of aryl binding site

Design, synthesis, and pharmacological evaluation of 2-amino-5-nitrothiazole derived semicarbazones as dual inhibitors of monoamine oxidase and cholinesterase: effect of the size of aryl binding site

A series of 2-amino-5-nitrothiazole derived semicarbazones were designed, synthesised and investigated for MAO and ChE inhibition properties. Most of the compounds showed preferential inhibition towards MAO-B. Compound 4, (1-(1-(4-Bromophenyl)ethylidene)-4-(5-nitrothiazol-2-yl)semicarbazide) emerged...

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Bibliographic Details
Main Authors: Rati K. P. Tripathi, Vishnu M. Sasi, Sukesh K. Gupta, Sairam Krishnamurthy, Senthil R. Ayyannan
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
2-Amino-5-nitrothiazole
monoamine oxidase
Cholinesterase
dual inhibitors
molecular docking
Online Access:http://dx.doi.org/10.1080/14756366.2017.1389920

Internet

http://dx.doi.org/10.1080/14756366.2017.1389920

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