Synthetic multiantigen MVA vaccine COH04S1 protects against SARS-CoV-2 in Syrian hamsters and non-human primates

Synthetic multiantigen MVA vaccine COH04S1 protects against SARS-CoV-2 in Syrian hamsters and non-human primates

Abstract Second-generation COVID-19 vaccines could contribute to establish protective immunity against SARS-CoV-2 and its emerging variants. We developed COH04S1, a synthetic multiantigen modified vaccinia Ankara-based SARS-CoV-2 vaccine that co-expresses spike and nucleocapsid antigens. Here, we re...

Full description

Bibliographic Details
Main Authors: Flavia Chiuppesi, Vu H. Nguyen, Yoonsuh Park, Heidi Contreras, Veronica Karpinski, Katelyn Faircloth, Jenny Nguyen, Mindy Kha, Daisy Johnson, Joy Martinez, Angelina Iniguez, Qiao Zhou, Teodora Kaltcheva, Paul Frankel, Swagata Kar, Ankur Sharma, Hanne Andersen, Mark G. Lewis, Yuriy Shostak, Felix Wussow, Don J. Diamond
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-022-00436-6

Internet

https://doi.org/10.1038/s41541-022-00436-6

Similar Items