High-Mannose But Not Complex-Type Glycosylation of Tetherin Is Required for Restriction of HIV-1 Release

High-Mannose But Not Complex-Type Glycosylation of Tetherin Is Required for Restriction of HIV-1 Release

Tetherin is an interferon-inducible antiviral protein that inhibits the release of a broad spectrum of enveloped viruses by retaining virions at the surface of infected cells. While the role of specific tetherin domains in antiviral activity is clearly established, the role of glycosylation in tethe...

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Bibliographic Details
Main Authors: Abdul A. Waheed, Ariana Gitzen, Maya Swiderski, Eric O. Freed
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Viruses
Subjects:
human immunodeficiency virus
tetherin
mutant
N-linked glycosylation
glycosylation inhibitors
cell surface
virus release
tunicamycin
kifunensine
Online Access:http://www.mdpi.com/1999-4915/10/1/26

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http://www.mdpi.com/1999-4915/10/1/26

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