Programmable Base Editing in Mycobacterium tuberculosis Using an Engineered CRISPR RNA-Guided Cytidine Deaminase

Programmable Base Editing in Mycobacterium tuberculosis Using an Engineered CRISPR RNA-Guided Cytidine Deaminase

Multidrug-resistant Mycobacterium tuberculosis (Mtb) infection seriously endangers global human health, creating an urgent need for new treatment strategies. Efficient genome editing tools can facilitate identification of key genes and pathways involved in bacterial physiology, pathogenesis, and dru...

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Bibliographic Details
Main Authors: Xin-Yuan Ding, Si-Shang Li, Yi-Man Geng, Mei-Yi Yan, Guo-Bao Li, Guo-Liang Zhang, Yi-Cheng Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Genome Editing
Subjects:
mycobacteria
cytidine deaminase
genome editing
CRISPR
base editing
Online Access:https://www.frontiersin.org/articles/10.3389/fgeed.2021.734436/full

Internet

https://www.frontiersin.org/articles/10.3389/fgeed.2021.734436/full

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