Isothermal chemical denaturation assay for monitoring protein stability and inhibitor interactions

Abstract Thermal shift assay (TSA) with altered temperature has been the most widely used method for monitoring protein stability for drug research. However, there is a pressing need for isothermal techniques as alternatives. This urgent demand arises from the limitations of TSA, which can sometimes...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Randa Mahran, Niklas Vello, Anita Komulainen, Morteza Malakoutikhah, Harri Härmä, Kari Kopra
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: Nature Portfolio 2023-11-01
Cyfres:Scientific Reports
Mynediad Ar-lein:https://doi.org/10.1038/s41598-023-46720-w