Adeno-associated virus 9 vector-mediated cardiac-selective expression of human secretory leukocyte protease inhibitor attenuates myocardial ischemia/reperfusion injury

Adeno-associated virus 9 vector-mediated cardiac-selective expression of human secretory leukocyte protease inhibitor attenuates myocardial ischemia/reperfusion injury

Protease enzymes contribute to the initiation of cardiac remodeling and heart failure after myocardial ischemic/reperfusion (I/R) injury. Protease inhibitors attenuate protease activity and limit left ventricular dysfunction and remodeling. Previous studies showed the cardioprotective effect of secr...

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Bibliographic Details
Main Authors: Podsawee Mongkolpathumrat, Nitirut Nernpermpisooth, Anusak Kijtawornrat, Faprathan Pikwong, Wannapat Chouyratchakarn, Rungrueang Yodsheewan, Sasimanas Unajak, Sarawut Kumphune
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
ischemic/reperfusion injury
secretory leukocyte protease inhibitor (SLPI)
gene therapy
cardiac selective expression
cardioprotection
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.976083/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2022.976083/full

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