Monoclonal enolase-1 blocking antibody ameliorates pulmonary inflammation and fibrosis

Monoclonal enolase-1 blocking antibody ameliorates pulmonary inflammation and fibrosis

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic fatal disease with limited therapeutic options. The infiltration of monocytes and fibroblasts into the injured lungs is implicated in IPF. Enolase-1 (ENO1) is a cytosolic glycolytic enzyme which could translocate onto the cell surf...

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Bibliographic Details
Main Authors: Wei-Ching Huang, Chi-Fen Chuang, Yung-Tsang Huang, I-Che Chung, Mao-Lin Chen, Tung-Yueh Chuang, Xiu-Li Yang, Yu-Yau Chou, Chih-Hsin Liu, Nai-Yu Chen, Chun-Jen Chen, Ta-Tung Yuan
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Respiratory Research
Subjects:
Enolase-1
Antibody
Plasmin
Migration
Fibroblasts
Monocytes
Online Access:https://doi.org/10.1186/s12931-023-02583-3

Internet

https://doi.org/10.1186/s12931-023-02583-3

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