Structural Basis for Vascular Endothelial Growth Factor Receptor Activation and Implications for Disease Therapy

Structural Basis for Vascular Endothelial Growth Factor Receptor Activation and Implications for Disease Therapy

Vascular endothelial growth factors (VEGFs) bind to membrane receptors on a wide variety of cells to regulate diverse biological responses. The VEGF-A family member promotes vasculogenesis and angiogenesis, processes which are essential for vascular development and physiology. As angiogenesis can be...

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Bibliographic Details
Main Authors: Faheem Shaik, Gary A. Cuthbert, Shervanthi Homer-Vanniasinkam, Stephen P. Muench, Sreenivasan Ponnambalam, Michael A. Harrison
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Biomolecules
Subjects:
angiogenesis
VEGFR
receptor tyrosine kinase
signal transduction
cancer
bevacizumab
Online Access:https://www.mdpi.com/2218-273X/10/12/1673

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