Poricoic acid A as a modulator of TPH-1 expression inhibits renal fibrosis modulating protein stability of β-catenin and β-catenin-mediated transcription

Background: Renal fibrosis is the common feature of chronic kidney disease (CKD). However, few drugs specifically target fibrogenesis due to the lack of an effective therapeutic target. Hence, it is urgent to find a therapeutic strategy that inhibits renal fibrosis. Here, we identified that poricoic...

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Bibliographic Details
Main Authors: Dan-Qian Chen, Xia-Qing Wu, Lin Chen, He-He Hu, Yan-Ni Wang, Ying-Yong Zhao
Format: Article
Language:English
Published: SAGE Publishing 2020-09-01
Series:Therapeutic Advances in Chronic Disease
Online Access:https://doi.org/10.1177/2040622320962648