Expression of Synj2bp in mouse liver regulates the extent of wrappER-mitochondria contact to maintain hepatic lipid homeostasis

Expression of Synj2bp in mouse liver regulates the extent of wrappER-mitochondria contact to maintain hepatic lipid homeostasis

Abstract Background In mouse liver hepatocytes, nearly half of the surface area of every mitochondrion is covered by wrappER, a wrapping-type of ER that is rich in fatty acids and synthesizes lipoproteins (VLDL) (Anastasia et al. in Cell Rep 34:108873, 2021; Hurtley in Science (80- ) 372:142–143, 20...

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Main Authors: Nicolò Ilacqua, Irene Anastasia, Danylo Aloshyn, Rana Ghandehari-Alavijeh, Emily Ann Peluso, Madelaine C. Brearley-Sholto, Leonardo V. Pellegrini, Andrea Raimondi, Thomas Q. de Aguiar Vallim, Luca Pellegrini
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Biology Direct
Subjects:
WrappER
Mitochondria
Inter-organelle contact
Synj2bp
Rrbp1
ApoE
Online Access:https://doi.org/10.1186/s13062-022-00344-8

Internet

https://doi.org/10.1186/s13062-022-00344-8

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