Antidepressant Mechanism of Traditional Chinese Medicine Formula Xiaoyaosan in CUMS-Induced Depressed Mouse Model via RIPK1-RIPK3-MLKL Mediated Necroptosis Based on Network Pharmacology Analysis

Antidepressant Mechanism of Traditional Chinese Medicine Formula Xiaoyaosan in CUMS-Induced Depressed Mouse Model via RIPK1-RIPK3-MLKL Mediated Necroptosis Based on Network Pharmacology Analysis

Background: Depression is a stress-related disorder that seriously threatens people’s physical and mental health. Xiaoyaosan is a classical traditional Chinese medicine formula, which has been used to treat mental depression since ancient times. More and more notice has been given to the relationshi...

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Bibliographic Details
Main Authors: Zhi-Yi Yan, Hai-Yan Jiao, Jian-Bei Chen, Kai-Wen Zhang, Xi-Hong Wang, You-Ming Jiang, Yue-Yun Liu, Zhe Xue, Qing-Yu Ma, Xiao-Juan Li, Jia-Xu Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Pharmacology
Subjects:
xiaoyaosan
chronic unpredictable mild stress
depression
necroptosis
neuroinflammation
microglial activation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.773562/full

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