The Flavin Reductase MsuE Is a Novel Nitroreductase that Can Efficiently Activate Two Promising Next-Generation Prodrugs for Gene-Directed Enzyme Prodrug Therapy

The Flavin Reductase MsuE Is a Novel Nitroreductase that Can Efficiently Activate Two Promising Next-Generation Prodrugs for Gene-Directed Enzyme Prodrug Therapy

Bacterial nitroreductase enzymes that can efficiently catalyse the oxygen-independent reduction of prodrugs originally developed to target tumour hypoxia offer great potential for expanding the therapeutic range of these molecules to aerobic tumour regions, via the emerging cancer strategy of gene-d...

Full description

Bibliographic Details
Main Authors: David F. Ackerley, Janine N. Copp, Laura K. Green, Mathew A. Storey, Elsie M. Williams, Jeff B. Smaill, Adam V. Patterson
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:Cancers
Subjects:
gene therapy
GDEPT
nitroaromatic prodrug
nitroreductase
CB1954
PR-104A
Nitro-CBI-DEI
SOS chromotest
Online Access:http://www.mdpi.com/2072-6694/5/3/985

Internet

http://www.mdpi.com/2072-6694/5/3/985

Similar Items