Acute severe hypoxia induces apoptosis of human pluripotent stem cells by a HIF-1α and P53 independent mechanism

Acute severe hypoxia induces apoptosis of human pluripotent stem cells by a HIF-1α and P53 independent mechanism

Abstract Human embryonic and induced pluripotent stem cells are self-renewing pluripotent stem cells (hPSCs) that can differentiate into a wide range of specialized cells. Although moderate hypoxia (5% O2) improves hPSC self-renewal, pluripotency, and cell survival, the effect of acute severe hypoxi...

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Bibliographic Details
Main Authors: Sofía Mucci, Luciana Isaja, María Soledad Rodríguez-Varela, Sofía Luján Ferriol-Laffouillere, Mariela Marazita, Guillermo Agustín Videla-Richardson, Gustavo Emilio Sevlever, María Elida Scassa, Leonardo Romorini
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-23650-7

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https://doi.org/10.1038/s41598-022-23650-7

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