A predictive in vitro risk assessment platform for pro-arrhythmic toxicity using human 3D cardiac microtissues

Abstract Cardiotoxicity of pharmaceutical drugs, industrial chemicals, and environmental toxicants can be severe, even life threatening, which necessitates a thorough evaluation of the human response to chemical compounds. Predicting risks for arrhythmia and sudden cardiac death accurately is critic...

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Bibliographic Details
Main Authors: Celinda M. Kofron, Tae Yun Kim, Fabiola Munarin, Arvin H. Soepriatna, Rajeev J. Kant, Ulrike Mende, Bum-Rak Choi, Kareen L. K. Coulombe
Format: Article
Language:English
Published: Nature Portfolio 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-89478-9