Cellular mechanisms of combining innate immunity activation with PD-1/PD-L1 blockade in treatment of colorectal cancer

Cellular mechanisms of combining innate immunity activation with PD-1/PD-L1 blockade in treatment of colorectal cancer

Abstract PD-1/PD-L1 blockade therapies have displayed extraordinary clinical efficacy for melanoma, renal, bladder and lung cancer; however, only a minority of colorectal cancer (CRC) patients benefit from these treatments. The efficacy of PD-1/PD-L1 blockade in CRC is limited by the complexities of...

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Bibliographic Details
Main Authors: Qi Xie, Xiaolin Liu, Rengyun Liu, Jingxuan Pan, Jing Liang
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Molecular Cancer
Subjects:
Colorectal cancer
Innate immunity
PD-1/PD-L1 blockade
Combinational therapy
Cellular mechanism
Online Access:https://doi.org/10.1186/s12943-024-02166-w

Internet

https://doi.org/10.1186/s12943-024-02166-w

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