JIP3 links lysosome transport to regulation of multiple components of the axonal cytoskeleton

Rafiq et al. report that disruption of JIP3-dependent control of axonal lysosome transport in human neurons results in unexpected changes to the organization of multiple cytoskeletal proteins. This study provides new insights that improve our understanding of intellectual disabilities caused by muta...

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Bibliographic Details
Main Authors: N. M. Rafiq, L. L. Lyons, S. Gowrishankar, P. De Camilli, S. M. Ferguson
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02945-x