JIP3 links lysosome transport to regulation of multiple components of the axonal cytoskeleton
Rafiq et al. report that disruption of JIP3-dependent control of axonal lysosome transport in human neurons results in unexpected changes to the organization of multiple cytoskeletal proteins. This study provides new insights that improve our understanding of intellectual disabilities caused by muta...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-01-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02945-x |
| _version_ | 1798026238077435904 |
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| author | N. M. Rafiq L. L. Lyons S. Gowrishankar P. De Camilli S. M. Ferguson |
| author_facet | N. M. Rafiq L. L. Lyons S. Gowrishankar P. De Camilli S. M. Ferguson |
| author_sort | N. M. Rafiq |
| collection | DOAJ |
| description | Rafiq et al. report that disruption of JIP3-dependent control of axonal lysosome transport in human neurons results in unexpected changes to the organization of multiple cytoskeletal proteins. This study provides new insights that improve our understanding of intellectual disabilities caused by mutations in JIP3, and are relevant for neurodegenerative diseases associated with accumulations of lysosomes such as the Alzheimer’s disease |
| first_indexed | 2024-04-11T18:32:05Z |
| format | Article |
| id | doaj.art-75b8f26fc76946b1831b9a0a3b63c20c |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-11T18:32:05Z |
| publishDate | 2022-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-75b8f26fc76946b1831b9a0a3b63c20c2022-12-22T04:09:24ZengNature PortfolioCommunications Biology2399-36422022-01-015111010.1038/s42003-021-02945-xJIP3 links lysosome transport to regulation of multiple components of the axonal cytoskeletonN. M. Rafiq0L. L. Lyons1S. Gowrishankar2P. De Camilli3S. M. Ferguson4Department of Cell Biology, Yale University School of MedicineDepartment of Cell Biology, Yale University School of MedicineDepartment of Cell Biology, Yale University School of MedicineDepartment of Cell Biology, Yale University School of MedicineDepartment of Cell Biology, Yale University School of MedicineRafiq et al. report that disruption of JIP3-dependent control of axonal lysosome transport in human neurons results in unexpected changes to the organization of multiple cytoskeletal proteins. This study provides new insights that improve our understanding of intellectual disabilities caused by mutations in JIP3, and are relevant for neurodegenerative diseases associated with accumulations of lysosomes such as the Alzheimer’s diseasehttps://doi.org/10.1038/s42003-021-02945-x |
| spellingShingle | N. M. Rafiq L. L. Lyons S. Gowrishankar P. De Camilli S. M. Ferguson JIP3 links lysosome transport to regulation of multiple components of the axonal cytoskeleton Communications Biology |
| title | JIP3 links lysosome transport to regulation of multiple components of the axonal cytoskeleton |
| title_full | JIP3 links lysosome transport to regulation of multiple components of the axonal cytoskeleton |
| title_fullStr | JIP3 links lysosome transport to regulation of multiple components of the axonal cytoskeleton |
| title_full_unstemmed | JIP3 links lysosome transport to regulation of multiple components of the axonal cytoskeleton |
| title_short | JIP3 links lysosome transport to regulation of multiple components of the axonal cytoskeleton |
| title_sort | jip3 links lysosome transport to regulation of multiple components of the axonal cytoskeleton |
| url | https://doi.org/10.1038/s42003-021-02945-x |
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