MRP8/14 Is a Molecular Signature Triggered by Dopamine in HIV Latent Myeloid Targets That Increases HIV Transcription and Distinguishes HIV+ Methamphetamine Users with Detectable CSF Viral Load and Brain Pathology

MRP8/14 Is a Molecular Signature Triggered by Dopamine in HIV Latent Myeloid Targets That Increases HIV Transcription and Distinguishes HIV+ Methamphetamine Users with Detectable CSF Viral Load and Brain Pathology

There is a significant overlap between HIV infection and substance-use disorders. Dopamine (DA) is the most abundantly upregulated neurotransmitter in methamphetamine abuse, with receptors (DRD1-5) that are expressed by neurons as well as by a large diversity of cell types, including innate immune c...

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Bibliographic Details
Main Authors: Liana V. Basova, Alexander Lindsey, Annemarie McGovern, Ashley Rosander, Violaine Delorme-Walker, Wael M. ElShamy, Ved Vasishtha Pendyala, Peter Jesse Gaskill, Ronald J. Ellis, Mariana Cherner, Jennifer E. Iudicello, Maria Cecilia Garibaldi Marcondes
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Viruses
Subjects:
dopamine
biomarkers
methamphetamine
HIV
Online Access:https://www.mdpi.com/1999-4915/15/6/1363

Internet

https://www.mdpi.com/1999-4915/15/6/1363

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