The IL-33:ST2 axis is unlikely to play a central fibrogenic role in idiopathic pulmonary fibrosis

The IL-33:ST2 axis is unlikely to play a central fibrogenic role in idiopathic pulmonary fibrosis

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease (ILD) with limited treatment options. Interleukin-33 (IL-33) is proposed to play a role in the development of IPF however the exclusive use of prophylactic dosing regimens means that the therapeutic be...

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Bibliographic Details
Main Authors: Katherine E. Stephenson, Joanne Porte, Aoife Kelly, William A. Wallace, Catherine E. Huntington, Catherine L. Overed-Sayer, E. Suzanne Cohen, R. Gisli Jenkins, Alison E. John
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Respiratory Research
Subjects:
Idiopathic pulmonary fibrosis
IL-33
ST2
Fibroblasts
Bleomycin-induced pulmonary fibrosis
Precision-cut lung slices
Online Access:https://doi.org/10.1186/s12931-023-02334-4

Internet

https://doi.org/10.1186/s12931-023-02334-4

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