Targeting Immunometabolism Mediated by CD73 Pathway in EGFR-Mutated Non-small Cell Lung Cancer: A New Hope for Overcoming Immune Resistance

Targeting Immunometabolism Mediated by CD73 Pathway in EGFR-Mutated Non-small Cell Lung Cancer: A New Hope for Overcoming Immune Resistance

Despite the relevant antitumor efficacy of immunotherapy in advanced non-small cell lung cancer (NSCLC), the results in patients whose cancer harbors activating epidermal growth factor receptor (EGFR) mutations are disappointing. The biological mechanisms underlying immune escape and both unresponsi...

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Bibliographic Details
Main Authors: Anna Passarelli, Michele Aieta, Alessandro Sgambato, Cesare Gridelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
non-small cell lung cancer
epidermal growth factor receptor
immune metabolism
adenosine
CD73
immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01479/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.01479/full

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