Human ACE2 expression, a major tropism determinant for SARS-CoV-2, is regulated by upstream and intragenic elements.

Human ACE2 expression, a major tropism determinant for SARS-CoV-2, is regulated by upstream and intragenic elements.

Angiotensin-converting enzyme 2 (ACE2), part of the renin-angiotensin system (RAS), serves as an entry point for SARS-CoV-2, leading to viral proliferation in permissive cell types. Using mouse lines in which the Ace2 locus has been humanized by syntenic replacement, we show that regulation of basal...

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Bibliographic Details
Main Authors: John N Snouwaert, Leigh A Jania, Trang Nguyen, David R Martinez, Alexandra Schäfer, Nicholas J Catanzaro, Kendra L Gully, Ralph S Baric, Mark Heise, Martin T Ferris, Elizabeth Anderson, Katia Pressey, Jacob A Dillard, Sharon Taft-Benz, Victoria K Baxter, Jenny P-Y Ting, Beverly H Koller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011168

Internet

https://doi.org/10.1371/journal.ppat.1011168

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