Enantioselective synthesis of saddle-shaped eight-membered lactones with inherent chirality via organocatalytic high-order annulation

Abstract Inherently chiral medium-ring derivatives have important applications in many research fields, such as materials science, molecular recognition, and asymmetric catalysis. However, the enantioselective assembly of these molecules, especially by organocatalytic strategies, remains a formidabl...

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Bibliographic Details
Main Authors: Shao-Qing Shi, Chen-Chang Cui, Lin-Lin Xu, Jin-Peng Zhang, Wen-Juan Hao, Jianyi Wang, Bo Jiang
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-52823-3