The DNA helicase FANCJ (BRIP1) functions in double strand break repair processing, but not crossover formation during prophase I of meiosis in male mice.

The DNA helicase FANCJ (BRIP1) functions in double strand break repair processing, but not crossover formation during prophase I of meiosis in male mice.

Meiotic recombination between homologous chromosomes is initiated by the formation of hundreds of programmed double-strand breaks (DSBs). Approximately 10% of these DSBs result in crossovers (COs), sites of physical DNA exchange between homologs that are critical to correct chromosome segregation. V...

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Bibliographic Details
Main Authors: Tegan S Horan, Carolline F R Ascenção, Christopher Mellor, Meng Wang, Marcus B Smolka, Paula E Cohen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-02-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1011175&type=printable

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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1011175&type=printable

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