Inhibition of Oncogenic Kinases: An In Vitro Validated Computational Approach Identified Potential Multi-Target Anticancer Compounds

Inhibition of Oncogenic Kinases: An In Vitro Validated Computational Approach Identified Potential Multi-Target Anticancer Compounds

Tumorigenesis in humans is a multistep progression that imitates genetic changes leading to cell transformation and malignancy. Oncogenic kinases play a central role in cancer progression, rendering them putative targets for the design of anti-cancer drugs. The presented work aims to identify the po...

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Bibliographic Details
Main Authors: Nazia Ikram, Muhammad Usman Mirza, Michiel Vanmeert, Matheus Froeyen, Outi M. H. Salo-Ahen, Muhammad Tahir, Aamer Qazi, Sarfraz Ahmad
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Biomolecules
Subjects:
cancer
multi-target inhibitors
receptor tyrosine kinases
serine/threonine kinases
molecular dynamics simulations
molecular docking
in vitro
cell lines
Online Access:https://www.mdpi.com/2218-273X/9/4/124

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https://www.mdpi.com/2218-273X/9/4/124

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