Fasting, non-fasting and postprandial triglycerides for screening cardiometabolic risk
Fasting triacylglycerols have long been associated with cardiovascular disease (CVD) and other cardiometabolic conditions. Evidence suggests that non-fasting triglycerides (i.e. measured within 8 h of eating) better predict CVD than fasting triglycerides, which has led several organisations to recom...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2021-01-01
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| Series: | Journal of Nutritional Science |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2048679021000732/type/journal_article |
| _version_ | 1811155921207820288 |
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| author | Bryant H. Keirns Christina M. Sciarrillo Nicholas A. Koemel Sam R. Emerson |
| author_facet | Bryant H. Keirns Christina M. Sciarrillo Nicholas A. Koemel Sam R. Emerson |
| author_sort | Bryant H. Keirns |
| collection | DOAJ |
| description | Fasting triacylglycerols have long been associated with cardiovascular disease (CVD) and other cardiometabolic conditions. Evidence suggests that non-fasting triglycerides (i.e. measured within 8 h of eating) better predict CVD than fasting triglycerides, which has led several organisations to recommend non-fasting lipid panels as the new clinical standard. However, unstandardised assessment protocols associated with non-fasting triglyceride measurement may lead to misclassification, with at-risk individuals being overlooked. A third type of triglyceride assessment, postprandial testing, is more controlled, yet historically has been difficult to implement due to the time and effort required to execute it. Here, we review differences in assessment, the underlying physiology and the pathophysiological relevance of elevated fasting, non-fasting and postprandial triglycerides. We also present data suggesting that there may be a distinct advantage of postprandial triglycerides, even over non-fasting triglycerides, for early detection of CVD risk and offer suggestions to make postprandial protocols more clinically feasible. |
| first_indexed | 2024-04-10T04:42:56Z |
| format | Article |
| id | doaj.art-75c3ee6dd0844608b2db91d0a960ac22 |
| institution | Directory Open Access Journal |
| issn | 2048-6790 |
| language | English |
| last_indexed | 2024-04-10T04:42:56Z |
| publishDate | 2021-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Nutritional Science |
| spelling | doaj.art-75c3ee6dd0844608b2db91d0a960ac222023-03-09T12:38:46ZengCambridge University PressJournal of Nutritional Science2048-67902021-01-011010.1017/jns.2021.73Fasting, non-fasting and postprandial triglycerides for screening cardiometabolic riskBryant H. Keirns0Christina M. Sciarrillo1Nicholas A. Koemel2Sam R. Emerson3Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74075, USADepartment of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74075, USABoden Collaboration for Obesity, Nutrition, Exercise and Eating Disorders, The University of Sydney, Sydney, NSW 2006, Australia Sydney Medical School, The University of Sydney, Sydney, NSW 2006, AustraliaDepartment of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74075, USAFasting triacylglycerols have long been associated with cardiovascular disease (CVD) and other cardiometabolic conditions. Evidence suggests that non-fasting triglycerides (i.e. measured within 8 h of eating) better predict CVD than fasting triglycerides, which has led several organisations to recommend non-fasting lipid panels as the new clinical standard. However, unstandardised assessment protocols associated with non-fasting triglyceride measurement may lead to misclassification, with at-risk individuals being overlooked. A third type of triglyceride assessment, postprandial testing, is more controlled, yet historically has been difficult to implement due to the time and effort required to execute it. Here, we review differences in assessment, the underlying physiology and the pathophysiological relevance of elevated fasting, non-fasting and postprandial triglycerides. We also present data suggesting that there may be a distinct advantage of postprandial triglycerides, even over non-fasting triglycerides, for early detection of CVD risk and offer suggestions to make postprandial protocols more clinically feasible.https://www.cambridge.org/core/product/identifier/S2048679021000732/type/journal_articleCardiometabolicCardiovascular diseaseFasting triglyceridesNon-fasting triglyceridesPostprandial triglyceridesRisk screeningTriglyceride-rich lipoproteins |
| spellingShingle | Bryant H. Keirns Christina M. Sciarrillo Nicholas A. Koemel Sam R. Emerson Fasting, non-fasting and postprandial triglycerides for screening cardiometabolic risk Journal of Nutritional Science Cardiometabolic Cardiovascular disease Fasting triglycerides Non-fasting triglycerides Postprandial triglycerides Risk screening Triglyceride-rich lipoproteins |
| title | Fasting, non-fasting and postprandial triglycerides for screening cardiometabolic risk |
| title_full | Fasting, non-fasting and postprandial triglycerides for screening cardiometabolic risk |
| title_fullStr | Fasting, non-fasting and postprandial triglycerides for screening cardiometabolic risk |
| title_full_unstemmed | Fasting, non-fasting and postprandial triglycerides for screening cardiometabolic risk |
| title_short | Fasting, non-fasting and postprandial triglycerides for screening cardiometabolic risk |
| title_sort | fasting non fasting and postprandial triglycerides for screening cardiometabolic risk |
| topic | Cardiometabolic Cardiovascular disease Fasting triglycerides Non-fasting triglycerides Postprandial triglycerides Risk screening Triglyceride-rich lipoproteins |
| url | https://www.cambridge.org/core/product/identifier/S2048679021000732/type/journal_article |
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