The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability

The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability

Abstract The hypoxia-inducible factors (HIF) are transcription factors that activate the adaptive hypoxic response when oxygen levels are low. The HIF transcriptional program increases oxygen delivery by inducing angiogenesis and by promoting metabolic reprograming that favors glycolysis. The two ma...

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Bibliographic Details
Main Authors: Maciej Jaśkiewicz, Adrianna Moszyńska, Jarosław Króliczewski, Aleksandra Cabaj, Sylwia Bartoszewska, Agata Charzyńska, Magda Gebert, Michał Dąbrowski, James F. Collawn, Rafal Bartoszewski
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Cellular & Molecular Biology Letters
Subjects:
Hypoxia
Human endothelial cells
HIF1A
EPAS1
HIF-1α
HIF-2α
Online Access:https://doi.org/10.1186/s11658-022-00408-7

Internet

https://doi.org/10.1186/s11658-022-00408-7

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