Stimulation of the rat subthalamic nucleus is neuroprotective following significant nigral dopamine neuron loss

Stimulation of the rat subthalamic nucleus is neuroprotective following significant nigral dopamine neuron loss

Deep brain stimulation of the subthalamic nucleus (STN-DBS) is efficacious in treating the motor symptoms of Parkinson's disease (PD). However, the impact of STN-DBS on the progression of PD is unknown. Previous preclinical studies have demonstrated that STN-DBS can attenuate the degeneration o...

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Bibliographic Details
Main Authors: A.L. Spieles-Engemann, M.M. Behbehani, T.J. Collier, S.L. Wohlgenant, K. Steece-Collier, K. Paumier, B.F. Daley, S. Gombash, L. Madhavan, G.T. Mandybur, J.W. Lipton, B.T. Terpstra, C.E. Sortwell
Format: Article
Language:English
Published: Elsevier 2010-07-01
Series:Neurobiology of Disease
Subjects:
Deep brain stimulation
Subthalamic nucleus
Parkinson's disease
Neuroprotection
6-hydroxydopamine
Stereology
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110000707

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http://www.sciencedirect.com/science/article/pii/S0969996110000707

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