Exome sequencing in schizophrenic patients with high levels of homozygosity identifies novel and extremely rare mutations in the GABA/glutamatergic pathways.
Inbreeding is a known risk factor for recessive Mendelian diseases and previous studies have suggested that it could also play a role in complex disorders, such as psychiatric diseases. Recent inbreeding results in the presence of long runs of homozygosity (ROHs) along the genome, which are also def...
| Main Authors: | , , , , , , , , , |
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| 格式: | 文件 |
| 语言: | English |
| 出版: |
Public Library of Science (PLoS)
2017-01-01
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| 丛编: | PLoS ONE |
| 在线阅读: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0182778&type=printable |