Anti-Inflammatory Activity of 1,4-Naphthoquinones Blocking P2X7 Purinergic Receptors in RAW 264.7 Macrophage Cells

Anti-Inflammatory Activity of 1,4-Naphthoquinones Blocking P2X7 Purinergic Receptors in RAW 264.7 Macrophage Cells

P2X7 receptors are ligand-gated ion channels activated by ATP and play a significant role in cellular immunity. These receptors are considered as a potential therapeutic target for the treatment of multiple inflammatory diseases. In the present work, using spectrofluorimetry, spectrophotometry, West...

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Bibliographic Details
Main Authors: Sergei A. Kozlovskiy, Evgeny A. Pislyagin, Ekaterina S. Menchinskaya, Ekaterina A. Chingizova, Yuriy E. Sabutski, Sergey G. Polonik, Galina N. Likhatskaya, Dmitry L. Aminin
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Toxins
Subjects:
1,4-naphthoquinones
Ca<sup>2+</sup> influx
YO-PRO-1 uptake
P2X7R
macrophages
ROS production
Online Access:https://www.mdpi.com/2072-6651/15/1/47

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https://www.mdpi.com/2072-6651/15/1/47

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