Functional characterization of aquaporin-4 specific T cells: towards a model for neuromyelitis optica.

Functional characterization of aquaporin-4 specific T cells: towards a model for neuromyelitis optica.

BACKGROUND: Antibodies to the water channel protein aquaporin-4 (AQP4), which is expressed in astrocytic endfeet at the blood brain barrier, have been identified in the serum of Neuromyelitis optica (NMO) patients and are believed to induce damage to astrocytes. However, AQP4 specific T helper cell...

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Bibliographic Details
Main Authors: Sudhakar Reddy Kalluri, Veit Rothhammer, Ori Staszewski, Rajneesh Srivastava, Franziska Petermann, Marco Prinz, Bernhard Hemmer, Thomas Korn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3021520?pdf=render

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http://europepmc.org/articles/PMC3021520?pdf=render

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