Designer Exosomes for Targeted Delivery of a Novel Therapeutic Cargo to Enhance Sorafenib-Mediated Ferroptosis in Hepatocellular Carcinoma

Designer Exosomes for Targeted Delivery of a Novel Therapeutic Cargo to Enhance Sorafenib-Mediated Ferroptosis in Hepatocellular Carcinoma

Sorafenib is one of the few effective first-line drugs approved for the treatment of advanced hepatocellular carcinoma (HCC). However, the development of drug resistance is common among individuals with HCC. Recent evidence indicated that the anticancer activity of sorafenib mainly relies on the ind...

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Bibliographic Details
Main Authors: Xiaoju Li, Qianqian Yu, Runze Zhao, Xinyan Guo, Chenlin Liu, Kuo Zhang, Wangqian Zhang, Jinghan Liu, Jinzheng Yu, Shuning Wang, Qiang Hao, Weina Li, Wei Zhang, Meng Li, Yingqi Zhang, Cun Zhang, Yuan Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
hepatocellular carcinoma
resistance
sorafenib
engineered exosome
ferroptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.898156/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.898156/full

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