Asymmetrical nucleosomal DNA signatures regulate transcriptional directionality

Summary: Despite the symmetrical structure of nucleosomes, in vitro studies have shown that transcription proceeds with different efficiency depending on the orientation of the DNA sequence around them. However, it is unclear whether this functional asymmetry is present in vivo and whether it could...

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Bibliographic Details
Main Authors: Alicia García, Laura Durán, Mar Sánchez, Sara González, Rodrigo Santamaría, Francisco Antequera
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723016170