The Rocky Road From Fed-Batch to Continuous Processing With E. coli

Escherichia coli still serves as a beloved workhorse for the production of many biopharmaceuticals as it fulfills essential criteria, such as having fast doubling times, exhibiting a low risk of contamination, and being easy to upscale. Most industrial processes in E. coli are carried out in fed-bat...

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Bibliographic Details
Main Authors: Julian Kopp, Christoph Slouka, Oliver Spadiut, Christoph Herwig
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2019.00328/full