Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies

Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies

Abstract Dementia with Lewy bodies (DLB) is pathologically defined by the cytoplasmic accumulation of alpha-synuclein (aSyn) within neurons in the brain. Predominately pre-synaptic, aSyn has been reported in various subcellular compartments in experimental models. Indeed, nuclear alpha-synuclein (aS...

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Bibliographic Details
Main Authors: David J. Koss, Daniel Erskine, Andrew Porter, Pawel Palmoski, Hariharan Menon, Olivia G. J. Todd, Marta Leite, Johannes Attems, Tiago F. Outeiro
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Acta Neuropathologica Communications
Subjects:
Alpha-synuclein
Dementia with Lewy bodies
Lewy body disease
Synucleinopathies
Nuclear pathology
Online Access:https://doi.org/10.1186/s40478-022-01403-x

Internet

https://doi.org/10.1186/s40478-022-01403-x

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