SMYD2 targets RIPK1 and restricts TNF-induced apoptosis and necroptosis to support colon tumor growth

SMYD2 targets RIPK1 and restricts TNF-induced apoptosis and necroptosis to support colon tumor growth

Abstract SMYD2 is a histone methyltransferase, which methylates both histone H3K4 as well as a number of non-histone proteins. Dysregulation of SMYD2 has been associated with several diseases including cancer. In the present study, we investigated whether and how SMYD2 might contribute to colorectal...

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Bibliographic Details
Main Authors: Yu-qiang Yu, Veronika Thonn, Jay V. Patankar, Oana-Maria Thoma, Maximilian Waldner, Marta Zielinska, Li-li Bao, Miguel Gonzalez-Acera, Stefan Wallmüller, Felix B. Engel, Michael Stürzl, Markus F. Neurath, Eva Liebing, Christoph Becker
Format: Article
Language:English
Published: Nature Publishing Group 2022-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04483-0

Internet

https://doi.org/10.1038/s41419-021-04483-0

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