2-Iodo-4′-Methoxychalcone Attenuates Methylglyoxal-Induced Neurotoxicity by Activation of GLP-1 Receptor and Enhancement of Neurotrophic Signal, Antioxidant Defense and Glyoxalase Pathway

2-Iodo-4′-Methoxychalcone Attenuates Methylglyoxal-Induced Neurotoxicity by Activation of GLP-1 Receptor and Enhancement of Neurotrophic Signal, Antioxidant Defense and Glyoxalase Pathway

Methylglyoxal (MG) acts as a reactive precursor of advanced glycation end products (AGEs). This compound is often connected with pathologies such as diabetes, neurodegenerative processes and diseases of aging. 2-iodo-4′-methoxychalcone (CHA79), a synthetic halogen-containing chalcone deriv...

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Bibliographic Details
Main Authors: Yu-Ting Tseng, Yi-Hong Tsai, Ferenc Fülöp, Fang-Rong Chang, Yi-Ching Lo
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Molecules
Subjects:
halogen-containing chalcones
methylglyoxal
neurotrophic effect
antioxidant defense
glyoxalase pathway
neuroprotection
Online Access:https://www.mdpi.com/1420-3049/24/12/2249

Internet

https://www.mdpi.com/1420-3049/24/12/2249

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