GLP-1 Receptor Agonist NLY01 Reduces Retinal Inflammation and Neuron Death Secondary to Ocular Hypertension

GLP-1 Receptor Agonist NLY01 Reduces Retinal Inflammation and Neuron Death Secondary to Ocular Hypertension

Summary: Glaucoma is the leading cause of irreversible blindness and is characterized by the death of retinal ganglion cells (RGCs). Recent studies have implicated pro-inflammatory microglia, macrophages, and A1 astrocytes in the pathogenesis of neurodegenerative diseases. The role of pro-inflammato...

Full description

Bibliographic Details
Main Authors: Jacob K. Sterling, Modupe O. Adetunji, Samyuktha Guttha, Albert R. Bargoud, Katherine E. Uyhazi, Ahmara G. Ross, Joshua L. Dunaief, Qi N. Cui
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Cell Reports
Subjects:
glaucoma
neuroinflammation
intraocular pressure
A1 reactive astrocyte
NLY01
retinal ganglion cell
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720312602

Internet

http://www.sciencedirect.com/science/article/pii/S2211124720312602

Similar Items