Fluorescently labeled nuclear morphology is highly informative of neurotoxicity

Neurotoxicity can be detected in live microscopy by morphological changes such as retraction of neurites, fragmentation, blebbing of the neuronal soma and ultimately the disappearance of fluorescently labeled neurons. However, quantification of these features is often difficult, low-throughput, and...

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Bibliographic Details
Main Authors: Shijie Wang, Jeremy W. Linsley, Drew A. Linsley, Josh Lamstein, Steven Finkbeiner
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Toxicology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2022.935438/full