The Potential Role of the Intestinal Micromilieu and Individual Microbes in the Immunobiology of Chimeric Antigen Receptor T-Cell Therapy

The Potential Role of the Intestinal Micromilieu and Individual Microbes in the Immunobiology of Chimeric Antigen Receptor T-Cell Therapy

Cellular immunotherapy with chimeric antigen receptor (CAR)-T cells (CARTs) represents a breakthrough in the treatment of hematologic malignancies. CARTs are genetically engineered hybrid receptors that combine antigen-specificity of monoclonal antibodies with T cell function to direct patient-deriv...

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Bibliographic Details
Main Authors: Maria-Luisa Schubert, Roman Rohrbach, Michael Schmitt, Christoph K. Stein-Thoeringer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
microbiome
immunotherapy
antibiotic
CAR (chimeric antigen receptor) T cells
microbe-host association
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.670286/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.670286/full

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