Recombinant α<sub>1</sub>-Microglobulin (rA1M) Protects against Hematopoietic and Renal Toxicity, Alone and in Combination with Amino Acids, in a <sup>177</sup>Lu-DOTATATE Mouse Radiation Model

Recombinant α<sub>1</sub>-Microglobulin (rA1M) Protects against Hematopoietic and Renal Toxicity, Alone and in Combination with Amino Acids, in a <sup>177</sup>Lu-DOTATATE Mouse Radiation Model

<sup>177</sup>Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) is used clinically to treat metastasized or unresectable neuroendocrine tumors (NETs). Although <sup>177</sup>Lu-DOTATATE is mostly well tolerated in patients, bone marrow suppression and long-term renal t...

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Bibliographic Details
Main Authors: Abdul Ghani Alattar, Amanda Kristiansson, Helena Karlsson, Suvi Vallius, Jonas Ahlstedt, Eva Forssell-Aronsson, Bo Åkerström, Sven-Erik Strand, Johan Flygare, Magnus Gram
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Biomolecules
Subjects:
peptide receptor radionuclide therapy
α<sub>1</sub>-microglobulin
radiation
oxidative stress
bone marrow toxicity
renal damage
Online Access:https://www.mdpi.com/2218-273X/13/6/928

Internet

https://www.mdpi.com/2218-273X/13/6/928

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