Inhibition of human cytochromes P450 2A6 and 2A13 by flavonoids, acetylenic thiophenes and sesquiterpene lactones from Pluchea indica and Vernonia cinerea

Inhibition of human cytochromes P450 2A6 and 2A13 by flavonoids, acetylenic thiophenes and sesquiterpene lactones from Pluchea indica and Vernonia cinerea

The human liver cytochrome P450 (CYP) 2A6 and the respiratory CYP2A13 enzymes play role in nicotine metabolism and activation of tobacco-specific nitrosamine carcinogens. Inhibition of both enzymes could offer a strategy for smoking abstinence and decreased risks of respiratory diseases and lung can...

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Bibliographic Details
Main Authors: Supattra Boonruang, Khanistha Prakobsri, Phisit Pouyfung, Ekaruth Srisook, Aruna Prasopthum, Pornpimol Rongnoparut, Songklod Sarapusit
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
CYP2A6
CYP2A13
acetylenic thiophenes
sesquiterpene lactones
flavonoids
Online Access:http://dx.doi.org/10.1080/14756366.2017.1363741

Internet

http://dx.doi.org/10.1080/14756366.2017.1363741

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