Toll-Like Receptors Drive Specific Patterns of Tolerance and Training on Restimulation of Macrophages

Toll-Like Receptors Drive Specific Patterns of Tolerance and Training on Restimulation of Macrophages

Tolerance is a long-recognized property of macrophages that leads to an altered response to repeated or chronic exposure to endotoxin. The physiological role of tolerance is to limit the potential damage to host tissue that may otherwise result from prolonged production of pro-inflammatory cytokines...

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Bibliographic Details
Main Authors: Suzanne K. Butcher, Christine E. O’Carroll, Christine A. Wells, Ruaidhrí J. Carmody
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
tolerance
macrophage
toll-like receptor
transcriptome
innate immune memory
NF-κB
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00933/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00933/full

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