Senolytics To slOw Progression of Sepsis (STOP-Sepsis) in elderly patients: Study protocol for a multicenter, randomized, adaptive allocation clinical trial

Senolytics To slOw Progression of Sepsis (STOP-Sepsis) in elderly patients: Study protocol for a multicenter, randomized, adaptive allocation clinical trial

Abstract Background Senescent immune cells exhibit altered gene expression and resistance to apoptosis. The prevalence of these cells increases with age and emerging data implicate senescence-associated maladaptive signaling as a potential contributor to sepsis and septic shock. The senolytic drug f...

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Bibliographic Details
Main Authors: Milena Silva, David A. Wacker, Brian E. Driver, Abbey Staugaitis, Laura J. Niedernhofer, Elizabeth L. Schmidt, James L. Kirkland, Tamara Tchkonia, Tamara Evans, Carlos Hines Serrano, Steffen Ventz, Joseph S. Koopmeiners, Michael A. Puskarich, The STOP-Sepsis Investigators
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Trials
Subjects:
Sepsis
Septic shock
Senescence
Cellular senescence
Senolytic
Fisetin
Online Access:https://doi.org/10.1186/s13063-024-08474-2

Internet

https://doi.org/10.1186/s13063-024-08474-2

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