Senolytics To slOw Progression of Sepsis (STOP-Sepsis) in elderly patients: Study protocol for a multicenter, randomized, adaptive allocation clinical trial

Senolytics To slOw Progression of Sepsis (STOP-Sepsis) in elderly patients: Study protocol for a multicenter, randomized, adaptive allocation clinical trial

Abstract Background Senescent immune cells exhibit altered gene expression and resistance to apoptosis. The prevalence of these cells increases with age and emerging data implicate senescence-associated maladaptive signaling as a potential contributor to sepsis and septic shock. The senolytic drug f...

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Podrobná bibliografie
Hlavní autoři: Milena Silva, David A. Wacker, Brian E. Driver, Abbey Staugaitis, Laura J. Niedernhofer, Elizabeth L. Schmidt, James L. Kirkland, Tamara Tchkonia, Tamara Evans, Carlos Hines Serrano, Steffen Ventz, Joseph S. Koopmeiners, Michael A. Puskarich, The STOP-Sepsis Investigators
Médium: Článek
Jazyk:English
Vydáno: BMC 2024-10-01
Edice:Trials
Témata:
Sepsis
Septic shock
Senescence
Cellular senescence
Senolytic
Fisetin
On-line přístup:https://doi.org/10.1186/s13063-024-08474-2

Internet

https://doi.org/10.1186/s13063-024-08474-2

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